Award
National Institute of General Medical Sciences 5R01GM131079-08
Stereospecific Cross-Coupling Reactions as a Tool for Three Dimensional Molecular Diversification
Recipient
City College of New York
Award Amount
$326,560.00
Ceiling
$326,560.00
Awarded
May 13, 2026
Identifier
5R01GM131079-08
This NIH-funded project develops stereospecific cross-coupling reactions to manipulate molecular stereochemistry, facilitating rapid creation of enantiomerically pure drug candidates for biological assays.
Description
Using enantioenriched organometallic nucleophiles in transition metal-catalyzed carbon-carbon bond-forming reactions, the project aims to develop general tools for the rational manipulation of three-dimensional molecular structures. The goal is to enable rapid preparation of diverse libraries of single-enantiomer drug candidates for biological testing, focusing on derivatization of medicinally relevant frameworks and chiral motifs of pharmaceutical interest.