Award
NIH Reporter #5R01AI171408-05
The role of mammarenavirus defective interfering particles in protecting host fitness and the host-driven post-translational modifications that regulate their formation and function
Recipient
University of Vermont & St. College, Burlington, VT, United States
Award Amount
$598,271.00
Ceiling
$598,271.00
Awarded
August 14, 2026
Identifier
5R01AI171408-05
This NIH grant supports research on mammarenavirus defective interfering particles, focusing on their regulation and role in viral persistence and host fitness, using molecular and genetic approaches.
Description
The project aims to identify cellular processes that regulate defective interfering particles (DIPs) in mammarenaviruses, particularly focusing on their role in viral persistence and host fitness. The research involves understanding the molecular mechanisms, including host tyrosine kinases and ubiquitin ligases, that influence DIP formation and function. The study will utilize reverse genetic systems to engineer recombinant viruses that do not produce DIPs, enabling detailed pathogenesis studies in rodent reservoirs and incidental hosts.