Award
NIH Reporter #5R37CA263064-05
Characterizing the Risk of Chemotherapy Side Effects Based on Epigenetic Age and Modification by Resistance Training Intervention
Recipient
University of Hawaii at Manoa, Honolulu, HI, United States
Award Amount
$626,968.00
Ceiling
$626,968.00
Awarded
August 29, 2025
Identifier
5R37CA263064-05
Research project funded by the National Cancer Institute to study epigenetic age as a biomarker for chemotherapy side effects in colon cancer patients and the impact of resistance training on epigenetic aging.
Description
This study aims to evaluate whether epigenetic age can be used to identify colon cancer patients at high risk for chemotherapy toxicity, dose reductions, and delays, and whether resistance training can reduce the rate of epigenetic aging. It will also assess the relationship between epigenetic age in blood and tumor tissue with colorectal cancer subtypes and patient prognosis.