Award
National Institute of Allergy and Infectious Diseases 1P01AI196047-01
Project 2: Pre-Clinical Models and Phage Pharmacodynamics
Recipient
Stanford University
Award Amount
$358,218.00
Ceiling
$358,218.00
Awarded
March 30, 2026
Identifier
1P01AI196047-01
The project repurposes the CFTR-/- rat model to study respiratory phage therapy pharmacodynamics and host immune responses, aiming to optimize therapeutic regimens for chronic respiratory infections in Cystic Fibrosis.
Description
This project aims to establish and validate the CFTR-/- (CFTR-KO) rat model as a robust platform for evaluating respiratory phage therapy pharmacodynamics (PD), and host immune responses. The study addresses critical gaps in the field, enabling rigorous evaluation of phage therapy and protocol optimization. It involves using the P. aeruginosa phage cocktail KIM-C1 to investigate respiratory phage therapy and pharmacodynamics in a physiologically relevant model replicating key aspects of Cystic Fibrosis pathophysiology.