Award
National Institute of Allergy and Infectious Diseases 5K99AI182458-02
Elucidating a novel respiratory-mammary axis of T cell immunity
Recipient
Seattle Children's Hospital
Award Amount
$34,331.00
Ceiling
$34,331.00
Awarded
January 29, 2026
Identifier
5K99AI182458-02
NIH grant awarded to Seattle Children's Hospital to study T cell immunity in the respiratory and mammary systems, focusing on breastmilk's role in protecting infants from respiratory infections.
Description
This project aims to elucidate the respiratory-mammary axis of T cell immunity, focusing on the establishment, retention, and response of tissue resident memory T cells (TRM) in the lactating breast. It investigates the cellular origin of T cells in the upper respiratory tract and lactating breast, evaluates the impact of maternal and infant respiratory infections on breastmilk T cell subsets, and studies breastmilk antigen-specific TRM responses during maternal and infant RSV infections.