Award
University of California, San Francisco 1R35NS143000-01
The Developmental Transition of Neural Stem Cell Niches in the Human Brain
Recipient
University of California, San Francisco
Award Amount
$1,180,687.00
Ceiling
$1,180,687.00
Awarded
July 23, 2025
Identifier
1R35NS143000-01
Research project awarded to University of California, San Francisco to study neural stem cell niches in the human brain, focusing on neurogenesis and gliogenesis using advanced molecular and imaging techniques.
Description
This project aims to investigate the cellular composition and organization of the human CGE, focusing on neural progenitor cells and mechanisms of neurogenesis and gliogenesis. The work involves multi-omics, spatial transcriptomics, electron and light microscopy, and genetic approaches in mice. The goal is to understand how NSC niches transition from embryonic to postnatal stages and how progenitor cells persist and change, with implications for neurological disorders and tumor formation.