Award
NIH Reporter #1F30CA298427-01A1
Reprograming CAR T cells by targeting IKZF-HDAC mediated chromatin remodeling to treat breast cancer
Recipient
Medical College of Wisconsin, Milwaukee, WI
Award Amount
$45,669.00
Ceiling
$45,669.00
Awarded
May 19, 2026
Identifier
1F30CA298427-01A1
Research project funded by the National Cancer Institute to study epigenetic regulation of T cell exhaustion and develop improved CAR T cell therapies for breast cancer.
Description
This project investigates the mechanisms regulating CD8 T cell effector differentiation and function, focusing on epigenetic regulation by the IKZF family of transcription factors. The study aims to evaluate the efficacy of IKZF perturbation in cancer treatment and elucidate the molecular pathways involved, with the goal of developing novel therapeutic strategies to enhance CAR T cell efficacy in breast cancer.