Award
NIH Reporter #5R01DE029211-05
Essential role of amelogenin phosphorylation in tooth enamel formation
Recipient
University of Pittsburgh at Pittsburgh, PA
Award Amount
$446,443.00
Ceiling
$446,443.00
Awarded
September 14, 2020
Identifier
5R01DE029211-05
Research project funded by NIDCR to study the role of amelogenin phosphorylation in tooth enamel formation, using mouse models to understand enamel development and related diseases.
Description
This project aims to elucidate the critical role of amelogenin phosphorylation in enamel mineral formation using novel mouse models and advanced techniques. It builds on findings that phosphorylation of a single serine site (S-16) in amelogenin is essential for proper enamel structure, with knockout models showing disrupted enamel phenotypes.