National Institute of General Medical Sciences 1R35GM162132-01

Engineering radical enzymes for asymmetric olefin hydroalkylation

This award supports research on engineering glycyl radical enzymes to enable selective and efficient carbon-carbon bond formation for drug discovery and synthetic applications.

Description

The project aims to develop enzymatic methods to convert simple achiral starting materials into complex products in a single step, focusing on glycyl radical enzymes (GREs) as biocatalysts for selective and efficient C–C bond formation. The research includes investigating native substrate scopes, engineering enzyme variants, and understanding molecular mechanisms to advance drug discovery and synthetic routes to therapeutically relevant molecules.

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