Award
National Institute on Aging 3R01AG087280-02S1
The role of immune deregulation and NGF dysmetabolism in the development of Alzheimer disease in individuals with Down syndrome
Recipient
University of California-Irvine
Award Amount
$259,200.00
Ceiling
$259,200.00
Awarded
August 13, 2025
Identifier
3R01AG087280-02S1
A research project funded by the National Institute on Aging to study immune deregulation and NGF dysmetabolism in Alzheimer's disease development in individuals with Down syndrome, aiming to identify biomarkers and therapeutic targets.
Description
This project aims to investigate DS-specific pathophysiological mechanisms of Alzheimer's disease and identify novel biomarkers focusing on immune and NGF dysregulation at different stages of AD pathology in Down syndrome. The study uses biochemical analysis, neuropathological assessments, transcriptomics, proteomics, in vitro analyses, and a cohort of DS individuals to establish a model of the temporal relationship between immune and NGF dysregulation and AD-related neurodegenerative changes.