Award
National Institute on Aging 5U01AG088673-03
Examining the effect of cadmium metal exposure on Alzheimer's disease genetic alleles using herpes viral infected cerebral organoids
Recipient
University of Massachusetts Medical School Worcester, MA, United States
Award Amount
$837,485.00
Ceiling
$837,485.00
Awarded
July 10, 2026
Identifier
5U01AG088673-03
This award funds research investigating how cadmium exposure and herpes simplex virus infection affect Alzheimer's disease genetic variants using cerebral organoid models derived from induced pluripotent stem cells.
Description
The project aims to study the interaction of cadmium exposure, herpes simplex virus infection, and genetic variants in Alzheimer’s disease. The research involves reprogramming donor cell lines into iPSCs, differentiating into cerebral organoids, and analyzing AD-related phenotypes. The project includes RNA sequencing, flow cytometry, and cytokine measurement.