Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK139663-02
Role of Activin Type II Receptor Signaling in Muscle Hypertrophy, Obesity, and Weight Loss
Recipient
University of Pennsylvania, Philadelphia, PA
Award Amount
$752,121.00
Ceiling
$752,121.00
Awarded
December 15, 2025
Identifier
5R01DK139663-02
Research project funded by NIDDK to study activin type II receptor signaling's role in muscle hypertrophy and obesity, aiming to improve weight loss therapies that preserve muscle mass.
Description
The project aims to define the molecular mechanisms downstream of activin type II receptor signaling relevant to metabolic health. It explores the potential benefits of genetic or pharmacological blockade of this pathway, alone or combined with anorexic agents like GLP-1/GIP agonists, for weight loss in obesity.