Award
NIH Reporter #5F30DA057838-04
Intracellular signaling mechanisms underlying opioid modulation of pain
Recipient
Oregon Health & Science University
Award Amount
$33,420.00
Ceiling
$33,420.00
Awarded
February 18, 2026
Identifier
5F30DA057838-04
Research project funded by the National Institute on Drug Abuse to study intracellular signaling mechanisms of opioids in pain modulation using in vivo imaging and behavioral assays in mice.
Description
This project aims to define the temporal dynamics of mu opioid-induced PKA signaling within the mediodorsal thalamus (MD) to anterior cingulate cortex (ACC) circuitry, determine its causal relationship with pain relief, and examine cell-type specificity using in vivo imaging in mice. It involves in vivo imaging, behavioral pain assays, and molecular biology techniques to study opioid signaling pathways in the brain.