Award
NIH Reporter #3R01AG087280-03S1
The role of immune deregulation and NGF dysmetabolism in the development of Alzheimer disease in individuals with Down syndrome
Recipient
University of California, Irvine
Award Amount
$259,200.00
Ceiling
$259,200.00
Awarded
August 12, 2026
Identifier
3R01AG087280-03S1
Research project funded to study immune deregulation and NGF dysmetabolism in Alzheimer's disease development in individuals with Down syndrome, aiming to identify biomarkers and therapeutic targets.
Description
This project aims to investigate Down syndrome-specific mechanisms of Alzheimer's disease and identify novel biomarkers, focusing on immune and NGF dysregulation across Alzheimer's disease stages in Down syndrome. It combines neuropathological, cellular, and clinical studies to characterize immune and trophic factor alterations in Alzheimer's disease development in Down syndrome, informing future preventive trials, improving prediction of Alzheimer's disease onset, and identifying potential biomarkers and therapeutic targets.