Award
National Institute of Allergy and Infectious Diseases 5R21AI182899-02
Elucidating the regulatory mechanism of a Brucella-specific small RNA required for virulence
Recipient
Virginia Polytechnic Institute and State University
Award Amount
$228,146.00
Ceiling
$228,146.00
Awarded
November 18, 2024
Identifier
5R21AI182899-02
Research project funded by NIAID to study a Brucella-specific small RNA pathway essential for bacterial virulence, aiming to develop vaccines and therapeutics against Brucella infections.
Description
The proposed research will define a novel small regulatory RNA pathway in Brucella that may be targeted for vaccine and/or therapeutic development. Brucella spp. cause debilitating human infections and are potential biological weapons. The project aims to develop new therapeutic and vaccine strategies against human Brucella infection by studying the MavR-MurF genetic pathway critical for Brucella virulence.