Award
NIH Reporter #5R01CA258924-05
Genetic Predisposition to Chronic Lymphocytic Leukemia (CLL)
Recipient
Dana-Farber Cancer Institute, Boston, MA, United States
Award Amount
$591,132.00
Ceiling
$591,132.00
Awarded
April 21, 2025
Identifier
5R01CA258924-05
Research project funded by the National Cancer Institute to study genetic factors influencing Chronic Lymphocytic Leukemia, focusing on ATM gene variants and advanced genomic techniques to improve patient outcomes.
Description
This project aims to characterize the genetic basis of Chronic Lymphocytic Leukemia (CLL), focusing on germline variants, particularly in the ATM gene, and their role in disease susceptibility. The study involves enrolling CLL patients with ATM variants, functional assessment of ATM protein, expanding analysis with publicly available sequencing data, and exploring non-coding genome regions through ATAC-seq, whole genome, and RNA sequencing. The goal is to improve screening, counseling, and develop clinical trials for genetic testing utility.