Award
National Institute of Diabetes and Digestive and Kidney Diseases 7K08DK133674-04
Determining the Role of Brain-Derived CCN3 in Bone and Marrow Fat Metabolism
Recipient
Muriel Babey
Award Amount
$169,992.00
Ceiling
$169,992.00
Awarded
July 20, 2026
Identifier
7K08DK133674-04
A five-year research project led by Dr. Muriel Babey at Stanford University to study the role of brain-derived CCN3 in bone and marrow fat metabolism, focusing on aging and menopause, aiming to develop new treatments for osteoporosis.
Description
This application presents a five-year mentored research and training plan that will prepare Dr. Muriel Babey to be a leader in the field of skeletal, aging, and metabolic physiology. The project aims to determine the role of brain-derived cellular communication network factor 3 (CCN3) in bone and marrow fat metabolism, with a focus on aging, menopause, and dietary challenges. The research will utilize in vitro and in vivo models to assess how circulating CCN3 influences bone formation and marrow fat, ultimately aiming to develop novel therapeutic approaches for osteoporosis and fracture risk.