Award
National Institute of Allergy and Infectious Diseases 1R56AI200599-01
Host Restriction of Immune Escape HIV-1 Mutants
Recipient
Mehary Medical College, Nashville, TN, United States
Award Amount
$613,261.00
Ceiling
$613,261.00
Awarded
May 11, 2026
Identifier
1R56AI200599-01
NIH grant awarded to study molecular mechanisms of immune control and escape in HIV-1, focusing on specific mutations and host factor interactions to aid HIV/AIDS treatment development.
Description
This project aims to understand the molecular mechanisms that impose immune control of HIV-1 and enable HIV-1’s counter response and immune escape. The research focuses on the R264K mutation in HIV capsid protein and its interaction with host factors such as CypA, CPSF6, and the restriction protein TRIM5αhu. The study will investigate how these host factors influence viral DNA integration and restriction, with the goal of informing the development of innovative cure and treatment strategies for HIV/AIDS.