Award
NIH Reporter #5R01MH137602-02
Determining the relationship between NAAG and memory deficits in schizophrenia in mid- to late- life
Recipient
Johns Hopkins University, Baltimore, MD
Award Amount
$699,926.00
Ceiling
$699,926.00
Awarded
April 27, 2026
Identifier
5R01MH137602-02
This award funds a study by Johns Hopkins University to investigate the relationship between NAAG levels and memory deficits in schizophrenia patients and healthy adults aged 35 to 65, using magnetic resonance spectroscopy and functional MRI, aiming to inform future treatments and biomarker development.
Description
The proposed study will determine the link between N-acetyl-aspartyl-glutamate (NAAG) levels in the brain, memory performance, and memory task-related brain activity in patients with schizophrenia and healthy adults in mid- to late-life. Doing so will provide important insights for development of treatments aimed at modulation of NAAG levels to improve memory deficits in patients with schizophrenia and related memory disorders in mid- to late-life, as well as identify neuroimaging biomarkers for future relevant clinical trials.