NIH Reporter #5I01BX001176-13

Surfactant Protein C Mutations and Interstitial Lung Disease

The award supports research on lung epithelial dysfunction in Idiopathic Pulmonary Fibrosis using novel mouse models with Surfactant Protein C mutations to identify new therapeutic targets.

Description

This project involves generating and characterizing two novel mouse models expressing IPF-associated mutations in the Surfactant Protein C (SFTPC) gene, to study mechanisms of lung epithelial dysfunction, including cellular stress responses and metabolic reprogramming, with the goal of identifying new treatments for Idiopathic Pulmonary Fibrosis (IPF), a progressive interstitial lung disease affecting mainly older adults.

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