U.S. Department of Veterans Affairs Rhode Island 5IK2CX002603-03

Modeling the Treatment Response of Transcranial Magnetic Stimulation for Depression

The award funds a project to develop predictive models for transcranial magnetic stimulation treatment response in Veterans with depression, using clinical data from the VA TMS Pilot Program to optimize treatment outcomes.

Description

This project will utilize clinical data from several hundred Veterans who have received and will receive transcranial magnetic stimulation (TMS) for depression as part of the nationwide “VA TMS Pilot Program” to develop a generalized model of TMS treatment response. The project aims to replicate and expand a nonlinear modeling approach of the TMS treatment response that uses an exponential decay function to quantify the magnitude, speed, and outcomes of TMS treatment response. It will provide a comprehensive characterization of the total TMS treatment course and predict treatment outcomes based on early response. The work will leverage the largest dataset of TMS response in Veterans to date, potentially yielding tools applicable to many psychiatric interventions.

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