Award
National Institutes of Health 11014647
New insights into the molecular regulation of mechanotransduction
Recipient
Massachusetts Institute of Technology
Award Amount
$950,060.00
Ceiling
$950,060.00
Awarded
August 06, 2025
Identifier
11014647
The award supports research to elucidate the molecular mechanisms of mechanotransduction via integrin receptors and focal adhesions, using biochemical and cell-based methods to advance understanding of cellular responses to mechanical signals and their role in disease.
Description
This project aims to understand the molecular basis of mechanotransduction, focusing on integrin-dependent mechanotransduction and focal adhesion formation, growth, and molecular composition regulation. The research uses biochemical reconstitution and cell-based assays to study focal adhesion maturation, force transmission, and molecular composition regulation, challenging current dogma in the field.