Award
National Heart, Lung, and Blood Institute 5R01HL175471-02
Mechanisms of HIV-associated Hypertension
Recipient
Augusta University, Augusta, GA, United States
Award Amount
$669,900.00
Ceiling
$669,900.00
Awarded
August 21, 2025
Identifier
5R01HL175471-02
A research grant awarded to study the mechanisms by which HIV-associated proteins may contribute to hypertension and cardiovascular disease in people with HIV, using animal models and human specimens.
Description
This project aims to investigate whether HIV-derived proteins contribute to hypertension development, focusing on mechanisms involving IL-1α, Nox1, and T cell-mediated inflammation. The study will use genetically engineered animal models, human specimens, and cultured endothelial cells to test if HIV proteins accelerate cardiovascular aging via hypertension.