Award
National Institute on Drug Abuse 5R01DA058666-03
Short Sleep Duration as a Predictor of Methamphetamine Intake: Role of Orexin Mechanisms
Recipient
UNIVERSITY OF MISSISSIPPI MED CTR
Award Amount
$780,511.00
Ceiling
$780,511.00
Awarded
April 29, 2026
Identifier
5R01DA058666-03
This NIH-funded research project studies how short sleep duration influences methamphetamine intake through orexin mechanisms, using female rhesus monkeys to evaluate orexin receptor ligands' effects on sleep and drug reinforcement.
Description
The project investigates the role of orexin/hypocretin system in sleep and methamphetamine intake. The research involves female rhesus monkeys with short and normal sleep phenotypes. The project aims to evaluate the effects of orexin receptor ligands on sleep-wake cycles and methamphetamine reinforcement. The project is funded by NIH grant PA-20-185 and addresses public health concerns related to sleep and substance use disorders.