Award
National Heart, Lung, and Blood Institute 5R01HL175577-02
"Outside-in” Model of Cardiac Pacemaking: Extracellular Mediated Automaticity
Recipient
University of North Carolina Chapel Hill
Award Amount
$680,708.00
Ceiling
$680,708.00
Awarded
May 20, 2026
Identifier
5R01HL175577-02
Research project funded by NHLBI to study cardiac pacemaking mechanisms focusing on extracellular ionic dynamics in the sinoatrial node, aiming to improve understanding and treatment of arrhythmias.
Description
This project seeks to test a novel model of normal sinoatrial function to resolve inconsistencies in the field, uncovering the role of extracellular ionic fluctuations in pacemaking, defining how extracellular matrix composition influences sinoatrial node activity, and providing insight for next-generation therapeutics for human arrhythmias.