Award
National Institute of Dental and Craniofacial Research 4R01DE029951-02
Targeting Endosomal Receptors for Treatment of Chronic Pain
Recipient
National Institute of Dental and Craniofacial Research (NIDCR), part of NIH
Award Amount
$795,324.00
Ceiling
$795,324.00
Awarded
July 31, 2024
Identifier
4R01DE029951-02
NIH grant awarded to research endosomal GPCR signaling mechanisms for chronic pain treatment, aiming to develop novel therapeutic targets with improved pain relief and fewer side effects.
Description
The project aims to discover mechanisms of eGPCR signaling in neurons, investigate how eGPCRs regulate ion channels, and validate eGPCRs as therapeutic targets for chronic pain conditions including inflammatory, neuropathic, and cancer pain. The research involves biophysical, imaging, electrophysiological techniques, and nanoparticle-based drug delivery systems.