Award
National Institute of Allergy and Infectious Diseases 5R01AI081704-15
Transcriptional Regulation of C. albicans Cell Fate and Host Interactions
Recipient
Brown University
Award Amount
$478,500.00
Ceiling
$478,500.00
Awarded
July 15, 2026
Identifier
5R01AI081704-15
Research project funded by NIAID to study transcriptional regulation in Candida albicans, focusing on cell fate decisions and host interactions to identify therapeutic targets.
Description
This project examines the transcriptional regulation of key cell fate decisions in C. albicans including those controlling filamentation, biofilm formation, and phenotypic switching, and also addresses how this regulation contributes to commensal and pathogenic infections. The research investigates how transcription factors regulate developmental programs and form complexes through liquid-liquid phase separation driven by prion-like domains, aiming to understand pathogenicity and identify new therapeutic targets.