Award
National Heart, Lung, and Blood Institute 5R01HL179780-02
Gut Microbe-Derived Lipids Shape Chronic Inflammation in Cardiometabolic Disease
Recipient
Cleveland Clinic Lerner COM-CWRU
Award Amount
$728,435.00
Ceiling
$728,435.00
Awarded
March 04, 2026
Identifier
5R01HL179780-02
This award funds a project to study the role of gut microbe-derived lipids in chronic inflammation related to cardiometabolic diseases, aiming to develop probiotic therapies targeting these mechanisms.
Description
Research project investigating how gut microbe-derived lipids influence chronic inflammation in cardiometabolic diseases such as obesity, diabetes, and atherosclerosis, focusing on the microbial metabolite N-oleoyl serinol and its signaling via the host receptor GPR119 to suppress metainflammation.