Award
National Institute of Allergy and Infectious Diseases 1R37AI195421-01
Therapeutic vaccination to boost autologous neutralizing antibodies for ART free HIV Control
Recipient
University of Pennsylvania
Award Amount
$891,410.00
Ceiling
$891,410.00
Awarded
August 18, 2025
Identifier
1R37AI195421-01
Development of a personalized mRNA-LNP therapeutic vaccine to boost autologous neutralizing antibodies in HIV patients for ART-free virus control, tested in rhesus macaque models.
Description
This project aims to develop a personalized vaccine strategy to enhance autologous neutralizing antibodies in people with HIV, potentially leading to ART-free remission. It involves innovative immunogen design, mRNA-LNP delivery technology, and nonhuman primate models to test vaccine efficacy.