Award
National Institute of Allergy and Infectious Diseases 1R01AI187899-01A1
Optimizing lipid RVn monophosphate prodrugs to maximize RVn-triphosphate delivery
Recipient
University of California, San Diego, La Jolla, CA, United States
Award Amount
$3,082,513.00
Ceiling
$3,082,513.00
Awarded
July 18, 2025
Identifier
1R01AI187899-01A1
The project aims to optimize lipid nucleoside prodrugs to enhance oral bioavailability and tissue delivery of antivirals against RNA viruses, addressing a critical need for effective oral treatments.
Description
This NIH project focuses on developing broad-spectrum oral antivirals targeting RNA viruses, with a specific emphasis on lipid prodrug strategies to improve bioavailability and tissue targeting. The project involves in vitro and in vivo studies, including pharmacokinetics and efficacy testing in mice.