Award
National Cancer Institute 1R01CA302481-01A1
THE INTEGRATED STRESS RESPONSE IN GBM PATHOGENESIS AND RESPONSE TO THERAPY
Recipient
Massachusetts General Hospital
Award Amount
$659,201.00
Ceiling
$659,201.00
Awarded
May 26, 2026
Identifier
1R01CA302481-01A1
Award for research on the integrated stress response in glioblastoma, focusing on translational regulation and therapy response, funded by the National Cancer Institute.
Description
The project focuses on the role of the integrated stress response (ISR) in glioblastoma (GBM) pathogenesis and therapy response. The study aims to define the role of eIF2B in translational regulation, tumor growth, and therapy response. Investigates translational reprogramming mechanisms and targeted therapies involving aminoacyl-tRNA synthetases. Animal models are warranted due to limitations of cell culture and in silico models.