Award
NIH Reporter #5U01AI184071-04
Optimizing the diagnostic approach to cephalosporin allergy testing (DACAT Trial)
Recipient
Mayo Clinic Jacksonville, Jacksonville, FL, United States
Award Amount
$2,832,926.00
Ceiling
$2,832,926.00
Awarded
May 07, 2026
Identifier
5U01AI184071-04
A clinical trial funded by NIAID to improve diagnostic methods for cephalosporin allergy, assess cross-reactivity with beta-lactam antibiotics, and investigate underlying biological mechanisms to enhance future allergy diagnostics.
Description
This project includes a clinical trial and mechanistic studies to optimize the approach to cephalosporin allergy and advance future diagnostics. It aims to identify the optimal diagnostic approach to cephalosporin allergy, determine beta-lactam cross-reactivity, and discover the mechanism and antigenic determinants of cephalosporin allergy to advance future diagnostics.