Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5K08AR078372-04
The Role of Hormonal Dysregulation in Systemic Sclerosis
Recipient
Medical University of South Carolina, Charleston, SC
Award Amount
$186,469.00
Ceiling
$186,469.00
Awarded
August 21, 2025
Identifier
5K08AR078372-04
Research project funded to study the role of estrogen in fibrosis related to systemic sclerosis, aiming to develop targeted hormonal treatments.
Description
This project aims to understand how estrogen influences fibrosis in systemic sclerosis (SSc), a rare autoimmune disease, with the goal of developing targeted treatments using hormonal modulators. The research will identify estrogen receptors involved in fibrosis, analyze transcriptomic changes caused by estrogen, and explore associations between hormone levels and disease severity.