Award
National Institute of Neurological Disorders and Stroke 1K08NS138707-01A1
From Metabolic Stress to Energy Enhancement: Unraveling Complex V Dimerization in Mitochondrial Disorders
Recipient
Columbia University Health Sciences
Award Amount
$230,580.00
Ceiling
$230,580.00
Awarded
July 23, 2025
Identifier
1K08NS138707-01A1
This NIH-funded project investigates the role of ATP synthase dimerization defects in Leigh syndrome, aiming to understand mitochondrial energy failure and develop therapeutic strategies by enhancing ATP synthase dimerization.
Description
The proposed research focuses on Leigh syndrome (LS), a severe childhood mitochondrial disorder characterized by neurological regression and movement disorders. Building upon prior discovery of the USMG5 gene's association with LS, the project aims to elucidate the impact of ATP synthase dimerization defects on mitochondrial bioenergetics. The study will investigate the effects of metabolic stressors and explore strategies to enhance energy production, with the goal of developing new therapeutic approaches for mitochondrial diseases.