Award
National Institute of General Medical Sciences 2R35GM138023-06
The effects of synaptically released zinc on neuronal processing and brain function
Recipient
West Virginia University
Award Amount
$675,064.00
Ceiling
$675,064.00
Awarded
August 14, 2025
Identifier
2R35GM138023-06
Research project funded by NIGMS to study the role of synaptically released zinc in brain function and its impact on neurological disorders.
Description
This project investigates how synaptic zinc, released by zinc transporter 3 (ZnT3), affects neuronal processing and brain function. It aims to understand zinc release and clearance at synaptic terminals, its utilization by brain cells during synaptic transmission, and its regulatory effects on synaptic activity and structure. The research has implications for understanding neurological disorders such as schizophrenia and autism linked to zinc transporter mutations.