Award
NIH Reporter #5R01NS142622-02
Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia
Recipient
Virginia Commonwealth University, Richmond, VA
Award Amount
$634,383.00
Ceiling
$634,383.00
Awarded
April 01, 2026
Identifier
5R01NS142622-02
Research project funded by NINDS to study cholinergic degeneration's impact on cognitive fluctuations in Lewy body dementia, using MRI, EEG, and clinical assessments, aiming to develop new therapies.
Description
This project aims to elucidate the role of central cholinergic degeneration in cognitive fluctuations in Lewy body dementia (LBD). It will establish paradigms for assessing cognitive fluctuations in real-time using EEG, MRI, and clinical assessments, and evaluate the effects of cholinesterase inhibitors. The research aims to develop new therapeutic strategies targeting the cholinergic system to improve quality of life.