Award
NIH Reporter #5I21RX004644-04
Feasibility of Using PET Imaging for Detection of Treatment-Induced Changes in Chronic Neuroinflammation Following TBI
Recipient
Veterans Health Administration, Gainesville, FL, United States
Awarded
July 22, 2026
Identifier
5I21RX004644-04
This award supports research to develop PET imaging methods to detect chronic neuroinflammation after traumatic brain injury and to evaluate methylphenidate's effects on neuroinflammation and related disabilities using a rat model.
Description
The study aims to develop a preclinical platform for studying TBI-induced chronic neuroinflammation using PET imaging. It will evaluate the efficacy of methylphenidate in modulating neuroinflammation and related disabilities. The research involves a rat model of close-head TBI, with assessments including PET MRI imaging, behavioral tests (Morris Water Maze, Elevated Plus Maze), and immunohistochemistry for neuroinflammation markers.