Award
National Cancer Institute 5R37CA292807-02
Metabolic reprogramming to boost the fitness of anti-tumor immunity against metastatic colon cancer
Recipient
Cold Spring Harbor Laboratory
Award Amount
$640,583.00
Ceiling
$640,583.00
Awarded
May 05, 2026
Identifier
5R37CA292807-02
Award for research on metabolic reprogramming to improve anti-tumor immunity in metastatic colon cancer, funded by the National Cancer Institute, NIH.
Description
The project focuses on enhancing immunotherapy efficacy against metastatic colorectal cancer by activating the PPARĪ“-Cpt1a axis in CD8+ T cells. The project aims to delineate mechanisms, elucidate metabolic roles, and evaluate therapeutic potential using murine models and human organoids. The project is funded by the National Cancer Institute, NIH, under PA-20-185.