Award
National Institute of Allergy and Infectious Diseases (NIAID) 2R01AI145687-06A1
Structural definition of CD4-induced HIV-1 Env conformational changes required for infection
Recipient
Duke University
Award Amount
$807,497.00
Ceiling
$807,497.00
Awarded
July 25, 2025
Identifier
2R01AI145687-06A1
Research project to study HIV-1 Env conformational changes during infection to aid vaccine and drug development.
Description
The project investigates the stepwise conformational changes of the HIV-1 envelope (Env) protein during receptor-mediated entry into host cells. It focuses on early Env opening, the role of the fusion peptide (FP) in Env metastability, and the later stages where FP is buried within a hydrophobic core. The studies aim to advance understanding of HIV-1 entry mechanisms and inform vaccine and drug design.