Award
National Cancer Institute 1F30CA298663-01A1
PROX1-dependent epigenetic regulation of phenotypic plasticity during colorectal cancer metastasis
Recipient
WEILL MEDICAL COLL OF CORNELL UNIV
Award Amount
$54,538.00
Ceiling
$54,538.00
Awarded
July 15, 2025
Identifier
1F30CA298663-01A1
Research project funded by the National Cancer Institute to study the role of PROX1 in epigenetic regulation affecting colorectal cancer metastasis, aiming to identify therapeutic targets.
Description
This project investigates the role of PROX1, a transcriptional co-repressor, in modulating transcriptional and epigenetic programs that influence phenotypic plasticity in colorectal cancer metastasis. The research aims to understand how non-genetic phenotypic plasticity contributes to metastasis, focusing on PROX1's role in epigenetic regulation via the NuRD complex. The study explores how PROX1 constrains intestinal lineage identity through repressive epigenetic mechanisms involving the NuRD complex, and how its dysregulation promotes non-canonical lineage expression during metastasis. Using matched organoid models and mouse xenograft assays, the project aims to elucidate PROX1's epigenetic mechanisms and identify potential therapeutic targets.