Award
National Institute on Aging 5R01AG073189-03
Quantifying the contributions of mitochondrial DNA to Alzheimer's Disease and related conditions of aging
Recipient
Michigan State University, East Lansing, MI
Award Amount
$451,781.00
Ceiling
$451,781.00
Awarded
June 03, 2026
Identifier
5R01AG073189-03
This award funds the development and testing of a novel statistical model to estimate the contribution of mitochondrial DNA to Alzheimer's Disease and other aging-related conditions using large pedigree data linked to medical records.
Description
Development of a statistical model to estimate mitochondrial DNA effects on human disease, particularly Alzheimer's Disease and aging outcomes. The study will leverage the unique inheritance pattern of mtDNA, using multigenerational pedigrees linked to medical records, to estimate the variance attributable to mtDNA. The analysis will focus on Alzheimer's Disease, diabetes, suicide, Parkinson's Disease, and longevity.