Award
National Institute on Drug Abuse 5R01DA062024-02
Molecular determinants of ensemble recruitment by drugs of abuse
Recipient
Vanderbilt University, Nashville, TN
Award Amount
$1,115,682.00
Ceiling
$1,115,682.00
Awarded
March 31, 2026
Identifier
5R01DA062024-02
This award funds a research project at Vanderbilt University to study the molecular mechanisms by which cocaine activates specific neuronal ensembles in the brain's reward regions, aiming to uncover epigenetic factors that influence addiction progression and potential treatment strategies.
Description
Research project focused on understanding how cocaine-activated neuronal ensembles in the nucleus accumbens contribute to cocaine use disorder, investigating the role of the epigenetic regulator KAT2a in ensemble recruitment and maintenance using advanced molecular and imaging techniques.