Award
National Institute on Aging 1R21AG084931-01
Non-canonical Mechanisms and Unconventional Approaches to Activate AMPK and Glucose Uptake in the Skeletal Muscle of Older Rats
Recipient
University of Michigan at Ann Arbor
Award Amount
$429,000.00
Ceiling
$429,000.00
Awarded
June 25, 2024
Identifier
1R21AG084931-01
Research project funded by the National Institute on Aging to study non-canonical mechanisms activating AMPK to improve glucose uptake in skeletal muscle of older rats, aiming to develop interventions for age-related metabolic disorders.
Description
This project investigates the mechanisms to improve insulin sensitivity and glucose uptake in skeletal muscle of older rats, focusing on the role of AMP-activated protein kinase (AMPK). It explores non-canonical pathways and the effects of caloric restriction and a novel AMPK activator, aldometanib, on muscle glucose regulation. The research aims to inform strategies for healthy aging and potential interventions for age-related metabolic disorders.