Award
National Institute of General Medical Sciences 5R16GM149514-04
Identification of critical cellular pathways triggered by mitomycins interstrand crosslinks
Recipient
John Jay College of Criminal Justice
Award Amount
$162,658.00
Ceiling
$162,658.00
Awarded
June 12, 2026
Identifier
5R16GM149514-04
NIH grant awarded to John Jay College of Criminal Justice to study cellular pathways triggered by mitomycin-induced DNA crosslinks, focusing on p53-independent mechanisms for personalized cancer therapy.
Description
This project aims to identify critical cellular pathways triggered by DNA interstrand crosslinks (ICLs) produced by mitomycins, and to determine how the structure of these ICLs influences cellular signaling leading to cell death or cell cycle arrest, especially in the absence of functional p53. The study involves synthesizing different ICLs, analyzing their effects on DNA and cellular responses, and understanding how structural differences influence signaling outcomes. The goal is to develop targeted, personalized treatments for cancers with p53 mutations.