Award
NIH Reporter #5R21AI185486-02
Examining the influence of chromosome copy number on Pseudomonas aeruginosa persisters to fluoroquinolones
Recipient
Princeton University, Princeton, NJ, United States
Award Amount
$246,000.00
Ceiling
$246,000.00
Awarded
April 06, 2026
Identifier
5R21AI185486-02
Research grant awarded to study how chromosome copy number affects Pseudomonas aeruginosa's persistence to fluoroquinolone antibiotics, potentially improving treatment strategies.
Description
This project investigates the role of chromosome copy number (#Chr) in the persistence of Pseudomonas aeruginosa to fluoroquinolone antibiotics. It aims to determine if DNA repair or other processes mediate persister survival in a chromosome copy number-dependent manner, which could lead to new strategies to improve antibiotic efficacy against this opportunistic pathogen.