Award
National Institute on Alcohol Abuse and Alcoholism 1R01AA032476-01A1
Effects of perinatal ethanol exposure on immature respiratory control
Recipient
CASE WESTERN RESERVE UNIVERSITY
Award Amount
$550,442.00
Ceiling
$550,442.00
Awarded
July 22, 2026
Identifier
1R01AA032476-01A1
This award funds research on the effects of perinatal ethanol exposure on respiratory control in preterm infants and investigates choline as a potential protective treatment.
Description
The project focuses on understanding how ethanol exposure affects respiratory control in preterm infants and how choline supplementation could serve as a protective intervention. It aims to explore ethanol's impact on lipid rafts, neurotransmission, and neurophysiology in the nucleus tractus solitarius (nTS), and how choline can offer protection. The project will also analyze ethanol biomarkers in preterm infants to correlate exposure with developmental outcomes, ultimately guiding clinical trials for choline supplementation to reduce apnea and ethanol-related morbidity.