Award
National Cancer Institute 5R21CA294038-02
Synthetic Mechano-Transduction For Improved Cell Therapies In Immuno-Oncology
Recipient
Yale University
Award Amount
$235,212.00
Ceiling
$235,212.00
Awarded
December 11, 2025
Identifier
5R21CA294038-02
This NIH-funded project at Yale University develops mechano-transduction platforms to improve CAR T-cell therapies for cancer by enhancing immune receptor force measurement and engineering force transduction modules.
Description
The project aims to engineer therapeutic cells with force-responsive molecular devices to enhance their efficiency, leading to new strategies for cancer treatment. It focuses on harnessing mechanical forces in immune signaling, particularly in CAR T-cell therapies, to improve specificity and safety.