Award
National Institute of Dental and Craniofacial Research 5R01DE025221-09
MOLECULAR REGULATORY MECHANISM OF MESENCHYMAL STEM CELLS IN ADULT MOUSE INCISOR
Recipient
University of Southern California, Los Angeles, CA, United States
Award Amount
$434,693.00
Ceiling
$434,693.00
Awarded
December 02, 2025
Identifier
5R01DE025221-09
Research project funded by the National Institute of Dental and Craniofacial Research to study the regulatory mechanisms of mesenchymal stem cells in adult mouse incisors, focusing on stem cell niche and signaling for tissue regeneration.
Description
This project investigates how the transition of mesenchymal stem cells (MSCs) into transit amplifying cells (TACs) is regulated in the continuously growing adult mouse incisor to support tissue homeostasis. The study aims to reveal how the trigeminal nerve serves as a niche environment for MSCs and elucidate the signaling network regulating interactions between MSCs and TACs, potentially leading to new strategies for stem cell-mediated tissue regeneration.