Award
National Institute on Alcohol Abuse and Alcoholism 5K01AA030081-05
Basolateral amygdala to ventral subiculum network plasticity in alcohol dependent male and female rats
Recipient
Wake Forest University Health Sciences
Award Amount
$142,646.00
Ceiling
$142,646.00
Awarded
April 08, 2026
Identifier
5K01AA030081-05
Research project investigating neural circuit plasticity in alcohol dependent rats to understand withdrawal symptoms and develop better treatments.
Description
This project aims to study the role of posterior basolateral amygdala inputs to the ventral subiculum in alcohol dependent male and female rats, focusing on neural circuitry and neuroadaptations using advanced techniques such as ex vivo optogenetics, fiber photometry, and FISH RNAScope. The goal is to understand neural mechanisms responsible for negative affective symptoms during alcohol withdrawal and identify novel neural substrates for better treatments of alcohol use disorder.