# NIH Reporter #1R01CA308971-01A1

Multimodal approach to decipher CIC::DUX4 sarcoma

**Recipient:** University of Minnesota

**Award Amount:** $548,075.00
**Ceiling:** $548,075.00

**Awarded:** September 17, 2026

**Identifier:** 1R01CA308971-01A1

The project develops and uses mouse models to investigate how CIC::DUX4 drives sarcoma, examine interactions with the tumor immune environment, and test targeted P300/CBP inhibition.

### Description

Research project to study CIC::DUX4 sarcoma using mouse models, investigate mechanisms of tumor transformation and immune evasion, and evaluate P300/CBP inhibition as a potential therapeutic approach.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11447311)